Sociosexual stimuli affect ER- and PR-mRNA abundance in the hypothalamus of all-female whiptail lizards.
نویسندگان
چکیده
Hormone-dependent sociosexual behaviors of the displaying individual regulate the abundance of estrogen receptor- and progesterone receptor-mRNA in sex steroid hormone-concentrating brain areas of the partner. This effect of behavior on gene expression in the brain is independent of the gonads.
منابع مشابه
Progesterone inhibits female-typical receptive behavior and decreases hypothalamic estrogen and progesterone receptor messenger ribonucleic acid levels in whiptail lizards (genus Cnemidophorus).
Female-typical sexual behavior in tetrapods is mediated primarily by estrogen and progesterone acting through intracellular receptors at specific sites in the mediobasal hypothalamus. Progesterone exerts both faciliatory and inhibitory actions on female sexual behavior and in well-studied rodent models, the inhibitory actions are exerted through downregulation of progesterone and estrogen recep...
متن کاملSex differences in estrogen-induced progesterone and estrogen receptor mRNA in the ventromedial hypothalamus of hatchling whiptail lizards.
The ventromedial hypothalamus (VMH) is an important neural locus for the control of female-typical sexual behavior in vertebrates, and exogenous estrogen stimulates a strong increase in progesterone receptor (PR) in the VMH of adult females. Estrogen also regulates its own receptor (ER), though the direction of the response varies from species to species. In rodents and whiptail lizards, males ...
متن کاملEffect of long-term castration and long-term androgen treatment on sexually dimorphic estrogen-inducible progesterone receptor mRNA levels in the ventromedial hypothalamus of whiptail lizards.
In whiptail lizards, as in laboratory rodents, females will respond to exogenous estrogen by increasing progesterone receptor (PR) or PR mRNA in the ventromedial hypothalamus (VMH) while males show an attenuated response to the same treatment. In rodents, neonatal hormone manipulations affect the adult expression of this trait; however, few investigators have examined the effects of hormone tre...
متن کاملSexually dimorphic regulation of estrogen receptor alpha mRNA in the ventromedial hypothalamus of adult whiptail lizards is testosterone dependent.
Female, but not male, whiptail lizards will respond to exogenous estrogen with an increase in estrogen receptor alpha (ER alpha) mRNA in the ventromedial hypothalamus (VMH). The current study tested whether differences in long-term testosterone exposure may be responsible for this sex difference. In the first experiment, female whiptails were gonadectomized and implanted for 6 weeks with either...
متن کاملHormonal regulation of progesterone receptor mRNA expression in the hypothalamus of whiptail lizards: regional and species differences.
The effects of gonadal steroid hormones on steroid receptor mRNA expression vary across nuclei within the brain, between the sexes, and between species. We report that exogenous estrogen increases progesterone receptor (PR) mRNA levels in the periventricular preoptic area in an ancestor and descendant species pair of whiptail lizards, and also that this effect of estrogen is significantly stron...
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عنوان ژورنال:
- Brain research
دوره 741 1-2 شماره
صفحات -
تاریخ انتشار 1996